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How often can you take prednisone packs? Prednisone is usually taken with food one to four times a day or once every other day. Your doctor will probably tell you to take your dose(s) of prednisone at certain time(s) of day every day. Your personal dosing schedule will depend on your condition and on how you respond to treatment. Do predniSONE have aspirin in it? Prednisone Is Not So Kind On Your Stomach Prednisone can irritate the lining of your stomach and should always be taken with a meal. You are also more likely to get stomach ulcers if you take prednisone in combination with anti-inflammatories (such as ibuprofen or diclofenac) or aspirin.
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